Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced inflammation in COPD
نویسندگان
چکیده
منابع مشابه
A specific DAMP profile identifies susceptibility to smoke-induced airway inflammation.
7 A list of the Southampton Women's Survey Study Group members and their affiliations can be found in the Acknowledgements section. Hospital. The authors thank the children and their families who participated in the Southampton Women's Survey and all the research staff and computing staff.
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Activin-A is a pleiotropic cytokine belonging to the transforming growth factor-β superfamily and has been implicated in asthma and pulmonary fibrosis. However, the role of activin-A and its endogenous inhibitor, follistatin, in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unknown. We first quantified activin-A and follistatin in the lungs of air- or cigarette smoke-expos...
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BACKGROUND AND OBJECTIVE It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The a...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2016
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00135.2016